Describe the known causes of Harlequin Ichthyosis. Is it a flaw in DNA transcription/translation, or is it a form of gene suppression or expression? How do you know? Tumor specific antigens (TSAs) can arise in tumor cells from: O genetic mutations leading to mutated cellular proteins reactivation of normally silenced embryonic genes O self-peptides derived from normally expressed proteins O 0 over-expression of normal self-proteins

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