Explain how the RAAS system regulates sodium reabsorption and water retention. A 17-year old girl experienced 15 pressure-type headaches per month for the previous 8 months. Each headache lasted from 2 hours to 2 days. There has been no disturbance of her school performance or attendance. Her neurological examination is normal. Your intern asks you about the pathophysiology of this condition and you answer with the hypothesis of: a. Sensitization of myofascial nociceptors b. Lowered sensitivity of pain pathways in the CNS c. Mutation of nitric oxide gene d. Hereditary factors e. Mutation calcitonin gene leads to hyperalgesia

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