Where does the organism come from (what is the source of infection?)

– How does it enter the host?

– What cells/tissues does it first adhere to upon entry into the host? How does it adhere? (What virulence factors are used for attachment?)

– What activities in pathogenesis does the pertussis toxin perform, and how does it affect host immunity?

– At what stage will antibiotic treatment be useful? If the disease has passed that stage, how is it the individuals recover?

– Define “secondary infection.” What possible secondary infections are of concern?

– List 5 possible vaccine targets.

– In keeping with the reading for this course, what is a possible scenario as to why the B. pertussis infections have increased in the last few decades? What do many organisms with deuterostome development have in common? Embryos have pharyngeal pouches that may or may not form gill slits. The blastopore formed during gastrulation becomes the anus. Adults are bilaterally symmetrical. All have a spinal column.

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