Explain the molecular basis of muscle contraction by describing, step-by-step, the chemo-mechanical cycle (the full power stroke”) of the cytoskeletal motor protein involved. (15) 2) Describe how one would develop an ettective gene therapy for a genetic disorder. Be sure to discuss the relevant factors involved at each stepWhat are inclusion bodies, what leads to their formation and how can their formation be prevented? (3) 7) Briefly explain how the conformation of DNA as either euchromatin or heterochromatin affects gene expression. (3) 8) At what step, during next-generation sequencing, do duplicates get introduced? (2) 9) What is bridge amplification?
